Levosimendan as a rescue adjunct in amlodipine intoxication--a case report.

نویسندگان

  • M Gökhan Teker
  • Haluk Ozdemir
  • Leyla Saidoglu
  • Kerem Erkalp
  • Gökçen Başaranoğlu
چکیده

Calcium channel blockers (CCB) are the cardiovascular medicines most commonly associated with overdose death1. Amlodipine, a dihydropyridine CCB, can cause shock at overdose levels. The hemodynamic shock is likely caused by calcium channel blockade in myocardial smooth muscle and beta cells. This blockade leads to peripheral vasodilatation, hyperglycemia, hypoinsulinemia, metabolic acidosis and shock2. Here we describe the use of levosimendan, a calcium sensitizing agent, to treat a 16-year old woman who ingested 500 mg of amlodipine and failed to respond to conventional therapies including calcium salts, inotrope infusions and hyperinsulinemiaeuglycemia therapy.

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عنوان ژورنال:
  • Middle East journal of anaesthesiology

دوره 20 6  شماره 

صفحات  -

تاریخ انتشار 2010