Levosimendan as a rescue adjunct in amlodipine intoxication--a case report.
نویسندگان
چکیده
Calcium channel blockers (CCB) are the cardiovascular medicines most commonly associated with overdose death1. Amlodipine, a dihydropyridine CCB, can cause shock at overdose levels. The hemodynamic shock is likely caused by calcium channel blockade in myocardial smooth muscle and beta cells. This blockade leads to peripheral vasodilatation, hyperglycemia, hypoinsulinemia, metabolic acidosis and shock2. Here we describe the use of levosimendan, a calcium sensitizing agent, to treat a 16-year old woman who ingested 500 mg of amlodipine and failed to respond to conventional therapies including calcium salts, inotrope infusions and hyperinsulinemiaeuglycemia therapy.
منابع مشابه
Levosimendan as Treatment Option in Severe Verapamil Intoxication: A Case Report and Review of the Literature
Cardiovascular shock due to verapamil intoxication is often refractory to standard resuscitation methods. Recommended therapy includes prevention of further absorption of the drug, inotropic therapy, calcium gluconate, and hyperinsulinemia/euglycemia therapy. Often further measures are needed such as ventricular pacing or mechanical circulatory support. Still, mortality remains high. Levosimend...
متن کاملA Pragmatic Approach to Superwarfarin Intoxication in a Resource Constraint Setting; a Case Report
متن کامل
Curcin Intoxication in Royal Thai Army Privates: A Case Report
Background: Jatropha curcas,commonly known as “Saboo Dum,” is the most common plant poisoning in Thailand. Saboo Dum seeds are used as raw material for biodiesel fuel manufacture, especially in Royal Thai Military units. The seed contains a toxin called curcin which can cause hepatotoxicity in humans. Case Presentation: We reported twenty-eight private soldiers who were brought to the emergency...
متن کاملPeganum harmala intoxication, a case report
Objective: Peganum harmala (P. harmala), “Espand” in Persian, has small seeds and has been used in traditional medicine as emmenagogue and an abortifacient. It has various pharmacological effects such as antifungal, antibacterial, hypothermic, anticancer, antinociceptive, and reversible monoamine oxidase inhibition. Case details: This case was a 45 years old woman who ingested about 50 grams se...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Middle East journal of anaesthesiology
دوره 20 6 شماره
صفحات -
تاریخ انتشار 2010